Paraneoplastic Cerebellar Degeneration

Cerebellar degeneration associated with a remote neoplasm. Clinical manifestations include progressive limb and GAIT ATAXIA; DYSARTHRIA; and NYSTAGMUS, PATHOLOGIC. The histologic type of the associated neoplasm is usually carcinoma or lymphoma. Pathologically the cerebellar cortex and subcortical nuclei demonstrate diffuse degenerative changes. Anti-Purkinje cell antibodies (anti-Yo) are found in the serum of approximately 50% of affected individuals. (Adams et al., Principles of Neurology, 6th ed, p686)

Also Known As:

Anti-Yo-Associated Paraneoplastic Cerebellar Degeneration; Cerebellar Syndrome, Paraneoplastic; Paraneoplastic Cerebellar Syndrome; Anti Yo Associated Paraneoplastic Cerebellar Degeneration; Cerebellar Syndromes, Paraneoplastic; Degeneration, Paraneoplastic Cerebellar; Paraneoplastic Cerebellar Degeneration, Anti Yo Associated; Paraneoplastic Cerebellar Syndromes; Cerebellar Degeneration, Paraneoplastic; Paraneoplastic Cerebellar Degeneration, Anti-Yo-Associated

Neoplasms: 1361496
- Paraneoplastic Syndromes: 1109
  - Nervous System Paraneoplastic Syndromes: 132
    - Paraneoplastic Cerebellar Degeneration: 310
- Neoplasms by Site: 4
  - Nervous System Neoplasms: 237
    - Nervous System Paraneoplastic Syndromes: 132
      - Paraneoplastic Cerebellar Degeneration: 310
Nervous System Diseases: 14737
- Neurodegenerative Diseases: 44095
  - Nervous System Paraneoplastic Syndromes: 132
    - Paraneoplastic Cerebellar Degeneration: 310
- Central Nervous System Diseases: 4371
  - Brain Diseases: 16141
    - Cerebellar Diseases: 647
      - Paraneoplastic Cerebellar Degeneration: 310

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